Spontaneous Insertion of a B2 Element in the Ptpn6 Gene Drives a Systemic Autoinflammatory Disease in Mice Resembling Neutrophilic Dermatosis in Humans

We found a spontaneous autosomal mutation in a mouse leading to neutrophil infiltration with ulceration in the upper dermis of homozygous offspring. These animals had increased neutrophil numbers, associated with normal lymphocyte count, in peripheral blood and bone marrow, suggesting a myeloprolife...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Nesterovitch, Andrew B., Szanto, Sandor, Gonda, Andrea, Bardos, Tamas, Kis-Toth, Katalin, Adarichev, Vyacheslav A., Olasz, Katalin, Ghassemi-Najad, Sheida, Hoffman, Mark D., Tharp, Michael D., Mikecz, Katalin, Glant, Tibor T.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Investigative Pathology 2011
Θέματα:
Regular Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078426/
https://ncbi.nlm.nih.gov/pubmed/21435452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2010.12.053
Ετικέτες: Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

Παρόμοια τεκμήρια