Spontaneous Insertion of a B2 Element in the Ptpn6 Gene Drives a Systemic Autoinflammatory Disease in Mice Resembling Neutrophilic Dermatosis in Humans

We found a spontaneous autosomal mutation in a mouse leading to neutrophil infiltration with ulceration in the upper dermis of homozygous offspring. These animals had increased neutrophil numbers, associated with normal lymphocyte count, in peripheral blood and bone marrow, suggesting a myeloprolife...

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Main Authors: Nesterovitch, Andrew B., Szanto, Sandor, Gonda, Andrea, Bardos, Tamas, Kis-Toth, Katalin, Adarichev, Vyacheslav A., Olasz, Katalin, Ghassemi-Najad, Sheida, Hoffman, Mark D., Tharp, Michael D., Mikecz, Katalin, Glant, Tibor T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078426/
https://ncbi.nlm.nih.gov/pubmed/21435452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2010.12.053
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