Novel Role of Base Excision Repair in Mediating Cisplatin Cytotoxicity

Using isogenic mouse embryonic fibroblasts and human cancer cell lines, we show that cells defective in base excision repair (BER) display a cisplatin-specific resistant phenotype. This was accompanied by enhanced repair of cisplatin interstrand cross-links (ICLs) and ICL-induced DNA double strand b...

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Detalhes bibliográficos
Main Authors: Kothandapani, Anbarasi, Dangeti, Venkata Srinivas Mohan Nimai, Brown, Ashley R., Banze, Lauren A., Wang, Xiao-Hong, Sobol, Robert W., Patrick, Steve M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077654/
https://ncbi.nlm.nih.gov/pubmed/21357694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.225375
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