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GINS and Sld3 Compete with One Another for Mcm2-7 and Cdc45 Binding
Sld3 is essential for the initiation of DNA replication, but Sld3 does not travel with a replication fork. GINS binds to Cdc45 and Mcm2-7 to form the replication fork helicase in eukaryotes. We purified Sld3, Cdc45, GINS, and Mcm2-7 and studied their interaction and assembly into complexes. Sld3 bin...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3077617/ https://ncbi.nlm.nih.gov/pubmed/21362622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.218305 |
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