Llwytho...
Allosteric Control of Ligand Binding Affinity Using Engineered Conformation-Specific Effector Proteins
We describe a phage display methodology to engineer synthetic antigen binders (sABs) that recognize either the apo- or the ligand-bound conformation of maltose binding protein (MBP). sABs that preferentially recognize the maltose-bound form of MBP act as positive allosteric effectors by significantl...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2011
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3077571/ https://ncbi.nlm.nih.gov/pubmed/21378967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2002 |
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