Gamma-Secretase Inhibitor Treatment Promotes VEGF-A-Driven Blood Vessel Growth and Vascular Leakage but Disrupts Neovascular Perfusion

The Notch signaling pathway is essential for normal development due to its role in control of cell differentiation, proliferation and survival. It is also critically involved in tumorigenesis and cancer progression. A key enzyme in the activation of Notch signaling is the gamma-secretase protein com...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kalén, Mattias, Heikura, Tommi, Karvinen, Henna, Nitzsche, Anja, Weber, Holger, Esser, Norbert, Ylä-Herttuala, Seppo, Hellström, Mats
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2011
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077402/
https://ncbi.nlm.nih.gov/pubmed/21533193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018709
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