VEGF-A and PDGF-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels

Vessel stabilisation and the inhibition of side-effects such as tissue edema are essential in angiogenic gene therapy. Thus, combination gene transfers (GT) stimulating both endothelial cell and pericyte proliferation have become of interest. However, there is currently little data to support combin...

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Publicado no:Circ Res
Main Authors: Korpisalo, Petra, Karvinen, Henna, Rissanen, Tuomas T., Kilpijoki, Johanna, Marjomäki, Varpu, Baluk, Peter, McDonald, Donald M., Cao, Yihai, Eriksson, Ulf, Alitalo, Kari, Ylä-Herttuala, Seppo
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693290/
https://ncbi.nlm.nih.gov/pubmed/18832750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.182287
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