Gamma-Secretase Inhibitor Treatment Promotes VEGF-A-Driven Blood Vessel Growth and Vascular Leakage but Disrupts Neovascular Perfusion

The Notch signaling pathway is essential for normal development due to its role in control of cell differentiation, proliferation and survival. It is also critically involved in tumorigenesis and cancer progression. A key enzyme in the activation of Notch signaling is the gamma-secretase protein com...

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Detalhes bibliográficos
Main Authors: Kalén, Mattias, Heikura, Tommi, Karvinen, Henna, Nitzsche, Anja, Weber, Holger, Esser, Norbert, Ylä-Herttuala, Seppo, Hellström, Mats
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077402/
https://ncbi.nlm.nih.gov/pubmed/21533193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018709
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