C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo

Histone deacetylase inhibitors (HDACIs) have shown promising anti-tumor effects for a variety of malignancies, however, many tumors are reportedly resistant to them. In this study, we made a novel discovery that co-administration of HDACIs (Trichostatin A (TSA) and others) and exogenous cell-permeab...

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Detalhes bibliográficos
Main Authors: Zhu, Q-y, Wang, Z, Ji, C, Cheng, L, Yang, Y-l, Ren, J, Jin, Y-h, Wang, Q-j, Gu, X-j, Bi, Z-g, Hu, G, Yang, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077291/
https://ncbi.nlm.nih.gov/pubmed/21368888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.96
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