HIV Tat(1-72) and Opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines

Opiates exacerbate HIV-1 Tat(1-72)–induced release of key proinflammatory cytokines by astrocytes, which may accelerate HIV neuropathogenesis in opiate abusers. The release of monocyte chemoattractant protein-1 (MCP-1 or CCL2), in particular, is potentiated by opiate-HIV Tat interactions in vitro. A...

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Détails bibliographiques
Auteurs principaux: El-Hage, Nazira, Wu, Guanghan, Wang, Juan, Ambati, Jayakrishna, Knapp, Pamela E., Reed, Janelle L., Bruce-Keller, Annadora J., Hauser, Kurt F.
Format: Artigo
Langue:Inglês
Publié: 2006
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077280/
https://ncbi.nlm.nih.gov/pubmed/16206161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.20262
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