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Total synthesis and biological evaluation of marinopyrrole A and analogues

A five-step total synthesis of the antibiotic marinopyrrole A (1) is described. The developed synthetic technology enabled the synthesis of several marinopyrrole A analogues whose antibacterial properties against methicillin-resistant Staphylococcus aureus TCH1516 were evaluated.

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Détails bibliographiques
Auteurs principaux: Nicolaou, K. C., Simmons, Nicholas L., Chen, Jason S., Haste, Nina M., Nizet, Victor
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077031/
https://ncbi.nlm.nih.gov/pubmed/21499535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2010.09.059
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