ΔNp63α confers tumor cell resistance to cisplatin through the AKT1 transcriptional regulation

Strategies to address resistance to platin drugs are greatly needed in human epithelial cancers (e.g. ovarian, head/neck and lung) where platins are used widely and resistance occurs commonly. We found that upon ΔNp63α overexpression, AKT1 and phospho-AKT1 levels are up regulated in cancer cells. In...

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Huvudupphovsmän: Sen, Tanusree, Sen, Nilkantha, Brait, Mariana, Begum, Shahnaz, Chatterjee, Aditi, Hoque, Mohammad Obaidul, Ratovitski, Edward, Sidransky, David
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076926/
https://ncbi.nlm.nih.gov/pubmed/21266360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1481
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