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ATM kinase is a master switch for the ΔNp63α phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage

We previously found that the pro-apoptotic DNA damaging agent, cisplatin, mediated the proteasome-dependent degradation of ΔNp63α associated with its increased phosphorylated status. Since ΔNp63α usually plays an opposite role to p53 and TAp63 in human cancers, we tested the notion that phosphorylat...

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Bibliografski detalji
Glavni autori: Huang, Yiping, Sen, Tanusree, Nagpal, Jatin, Upadhyay, Sunil, Trink, Barry, Ratovitski, Edward, Sidransky, David
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069617/
https://ncbi.nlm.nih.gov/pubmed/18769144
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