Phospho-ΔNp63α is a key regulator of the cisplatin-induced microRNAome in cancer cells

Head and neck squamous cell carcinoma (HNSCC) cells exposed to cisplatin (CIS) displayed a dramatic ATM-dependent phosphorylation of ΔNp63α that leads to the transcriptional regulation of downstream mRNAs. Here, we report that phospho (p)-ΔNp63α transcriptionally deregulates miRNA expression after C...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Huang, Y, Chuang, A, Hao, H, Talbot, C, Sen, T, Trink, B, Sidransky, D, Ratovitski, E
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2011
Sujets:
Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131951/
https://ncbi.nlm.nih.gov/pubmed/21274007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.188
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