Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations

The response of a membrane-bound Kv1.2 ion channel to an applied transmembrane potential has been studied using molecular dynamics simulations. Channel deactivation is shown to involve three intermediate states of the voltage sensor domain (VSD), and concomitant movement of helix S4 charges 10–15 Å...

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Bibliographic Details
Main Authors: Delemotte, Lucie, Tarek, Mounir, Klein, Michael L., Amaral, Cristiano, Treptow, Werner
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076833/
https://ncbi.nlm.nih.gov/pubmed/21444776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102724108
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