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Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations
The response of a membrane-bound Kv1.2 ion channel to an applied transmembrane potential has been studied using molecular dynamics simulations. Channel deactivation is shown to involve three intermediate states of the voltage sensor domain (VSD), and concomitant movement of helix S4 charges 10–15 Å...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076833/ https://ncbi.nlm.nih.gov/pubmed/21444776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102724108 |
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