Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers

Molecular subtypes of serous ovarian cancer have been recently described. Using data from independent datasets including over 900 primary tumour samples, we show that deregulation of the Let-7 pathway is specifically associated with the C5 molecular subtype of serous ovarian cancer. DNA copy number...

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Main Authors: Helland, Åslaug, Anglesio, Michael S., George, Joshy, Cowin, Prue A., Johnstone, Cameron N., House, Colin M., Sheppard, Karen E., Etemadmoghadam, Dariush, Melnyk, Nataliya, Rustgi, Anil K., Phillips, Wayne A., Johnsen, Hilde, Holm, Ruth, Kristensen, Gunnar B., Birrer, Michael J., Pearson, Richard B., Børresen-Dale, Anne-Lise, Huntsman, David G., deFazio, Anna, Creighton, Chad J., Smyth, Gordon K., Bowtell, David D. L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076323/
https://ncbi.nlm.nih.gov/pubmed/21533284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018064
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