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Conformational Changes in the G Protein-Coupled Receptor Rhodopsin Revealed by Histidine Hydrogen–Deuterium Exchange
G protein-coupled receptors (GPCRs) are activated by ligand binding, allowing extracellular signals to be efficiently transmitted through the membrane to the G protein recognition site, 40 Å away. Utilizing His residues found spaced throughout the GPCR, rhodopsin, we used His hydrogen–deuterium exch...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3075965/ https://ncbi.nlm.nih.gov/pubmed/20939497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101502v |
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