Terminal N-Linked Galactose Is the Primary Receptor for Adeno-associated Virus 9

Sialylated glycans serve as cell surface attachment factors for a broad range of pathogens. We report an atypical example, where desialylation increases cell surface binding and infectivity of adeno-associated virus (AAV) serotype 9, a human parvovirus isolate. Enzymatic removal of sialic acid, but...

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Библиографические подробности
Главные авторы: Shen, Shen, Bryant, Kelli D., Brown, Sarah M., Randell, Scott H., Asokan, Aravind
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
Предметы:
Glycobiology and Extracellular Matrices
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075699/
https://ncbi.nlm.nih.gov/pubmed/21330365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.210922
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