A Third Metal Is Required for Catalytic Activity of the Signal-transducing Protein Phosphatase M tPphA

Protein phosphatase M (PPM) regulates key signaling pathways in prokaryotes and eukaryotes. Novel structures of bacterial PPM members revealed three divalent metal ions in their catalytic centers. The function of metal 3 (M3) remained unclear. To reveal its function, we created variants of tPphA fro...

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Main Authors: Su(苏, Jiyong, 纪勇), Schlicker, Christine, Forchhammer, Karl
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2011
主題:
Enzymology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075694/
https://ncbi.nlm.nih.gov/pubmed/21310952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036467
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