Malaria Drug Resistance is Associated with Defective DNA Mismatch Repair

Malarial parasites exhibit striking genetic plasticity, a hallmark of which is an ever-increasing rate of resistance to new drugs, especially in Southeast Asia where multi-drug resistance (MDR) threatens the last line of antimalarial drugs, the artesunate compounds. Previous studies quantified the a...

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Main Authors: Castellini, Meryl A., Buguliskis, Jeffrey S., Casta, Louis J., Butz, Charles E., Clark, Alan B., Kunkel, Thomas A., Taraschi, Theodore F.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075314/
https://ncbi.nlm.nih.gov/pubmed/21315772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2011.02.004
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