The eps8 Family of Proteins Links Growth Factor Stimulation to Actin Reorganization Generating Functional Redundancy in the Ras/Rac Pathway

Sos-1, a guanine nucleotide exchange factor (GEF), eps8 and Abi1, two signaling proteins, and the lipid kinase phosphoinositide 3-kinase (PI3-K), assemble in a multimolecular complex required for Rac activation leading to actin cytoskeletal remodeling. Consistently, eps8 –/– fibroblasts fail to form...

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Main Authors: Offenhäuser, Nina, Borgonovo, Alessandro, Disanza, Andrea, Romano, Pascale, Ponzanelli, Isabella, Iannolo, Gioacchin, Di Fiore, Pier Paolo, Scita, Giorgio
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2004
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC307530/
https://ncbi.nlm.nih.gov/pubmed/14565974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-06-0427
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