A tingling sanshool derivative excites primary sensory neurons and elicits nocifensive behavior in rats

Szechuan peppers contain hydroxy-α-sanshool that imparts desirable tingling, cooling, and numbing sensations. Hydroxy-α-sanshool activates a subset of sensory dorsal root ganglion (DRG) neurons by inhibiting two-pore potassium channels. We presently investigated if a tingle-evoking sanshool analog,...

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Detalhes bibliográficos
Main Authors: Klein, Amanda H., Sawyer, Carolyn M., Zanotto, Karen L., Ivanov, Margaret A., Cheung, Susan, Carstens, Mirela Iodi, Furrer, Stephan, Simons, Christopher T., Slack, Jay P., Carstens, E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075278/
https://ncbi.nlm.nih.gov/pubmed/21273322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00922.2010
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