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Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection

T cells bearing αβ receptors recognize antigenic peptides bound to class I and class II glycoproteins encoded in the major histocompatibility complex (MHC). Cytotoxic and helper T cells respond respectively to peptide antigens derived from endogenous sources presented by MHC class I, and exogenous s...

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Autors principals: Sadegh-Nasseri, Scheherazade, Natarajan, Sateesh, Chou, Chih-Ling, Hartman, Isamu Z., Narayan, Kedar, Kim, AeRyon
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075107/
https://ncbi.nlm.nih.gov/pubmed/20066513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12026-009-8138-1
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