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HLA-DO as the Optimizer of Epitope Selection for MHC Class II Antigen Presentation

Processing of antigens for presentation to helper T cells by MHC class II involves HLA-DM (DM) and HLA-DO (DO) accessory molecules. A mechanistic understanding of DO in this process has been missing. The leading model on its function proposes that DO inhibits the effects of DM. To directly study DO...

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Autori principali: Poluektov, Yuri O., Kim, AeRyon, Hartman, Isamu Z., Sadegh-Nasseri, Scheherazade
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738515/
https://ncbi.nlm.nih.gov/pubmed/23951115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071228
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