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Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling
Hepcidin negatively regulates systemic iron homeostasis in response to inflammation and elevated serum iron. Conversely, hepcidin expression is diminished in response to hypoxia, oxidative stress, and increased erythropoietic demand, though the molecular intermediates involved are incompletely under...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3074628/ https://ncbi.nlm.nih.gov/pubmed/21289291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00121.2010 |
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