Cleavage properties of an oligonucleotide containing a bridged internucleotide 5'-phosphorothioate RNA linkage.

An oligonucleotide has been synthesized that contains a single bridging 5'-phosphorothioate at an RNA linkage (5'-ApCpGpGpTpCpTprCpsApCpGpApGpC-3'). This new phosphodiester linkage is found to be particularly susceptible to cleavage when compared with the corresponding oxo, deoxy and...

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Bibliographic Details
Main Authors: Kuimelis, R G, McLaughlin, L W
Format: Artigo
Language:Inglês
Published: 1995
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC307461/
https://ncbi.nlm.nih.gov/pubmed/8532515
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