The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines

BACKGROUND: Curcumin is a naturally occurring phenolic compound shown to have a wide variety of antitumor activities; however, it does not attain sufficient blood levels to do so when ingested. Using structure-based design, a novel compound, FLLL32, was generated from curcumin. FLLL32 possesses supe...

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Main Authors: Fossey, Stacey L, Bear, Misty D, Lin, Jiayuh, Li, Chenglong, Schwartz, Eric B, Li, Pui-Kai, Fuchs, James R, Fenger, Joelle, Kisseberth, William C, London, Cheryl A
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074561/
https://ncbi.nlm.nih.gov/pubmed/21443800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-112
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