The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

BACKGROUND: We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin. We hypothesized this lead compound would specifically inhibit the STAT3 signaling pathway to induce apoptosis in melanoma cells. RESULTS: FLLL32 spec...

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Bibliografiska uppgifter
Huvudupphovsmän: Bill, Matthew A, Fuchs, James R, Li, Chenglong, Yui, Jennifer, Bakan, Courtney, Benson, Don M, Schwartz, Eric B, Abdelhamid, Dalia, Lin, Jiayuh, Hoyt, Dale G, Fossey, Stacey L, Young, Gregory S, Carson, William E, Li, Pui-Kai, Lesinski, Gregory B
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2010
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902420/
https://ncbi.nlm.nih.gov/pubmed/20576164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-165
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