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Gene amplification in human cells knocked down for RAD54

BACKGROUND: In mammalian cells gene amplification is a common manifestation of genome instability promoted by DNA double-strand breaks (DSBs). The repair of DSBs mainly occurs through two mechanisms: non-homologous end-joining (NHEJ) and homologous recombination (HR). We previously showed that defec...

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Autors principals: Ruiz-Herrera, Aurora, Smirnova, Alexandra, Khouriauli, Lela, Nergadze, Solomon G, Mondello, Chiara, Giulotto, Elena
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074559/
https://ncbi.nlm.nih.gov/pubmed/21418575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2041-9414-2-5
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