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A monoclonal antibody extends the half-life of an anti-HIV oligodeoxynucleotide and targets it to CD4+ cells.

An approach was sought to increase the half-life and target cell specificity of antisense oligodeoxynucleotides (oligos). A monoclonal antibody (MAb) was derived from mice immunised with an oligo complementary to a region (1-20) of the HIV genome. This MAb exerts a protective effect on the oligo fro...

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Detalhes bibliográficos
Main Authors: Morelli, D, Pozzi, B, Maier, J A, Ménard, S, Colnaghi, M I, Balsari, A
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC307432/
https://ncbi.nlm.nih.gov/pubmed/8524649
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