In vitro and in vivo stability and anti-tumour efficacy of an anti-EGFR/anti-CD3 F(ab')2 bispecific monoclonal antibody.

The in vitro and in vivo stability and anti-tumour efficacy of the anti-EGFR/anti-CD3 bispecific monoclonal antibody (biMAb), M26.1, were analysed. The interaction of the intact biMAb with Fc receptor I (Fc gamma RI) present on human leucocytes was not observed when the antibody was used as an F(ab&...

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Main Authors: Negri, D. R., Tosi, E., Valota, O., Ferrini, S., Cambiaggi, A., Sforzini, S., Silvani, A., Ruffini, P. A., Colnaghi, M. I., Canevari, S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034020/
https://ncbi.nlm.nih.gov/pubmed/7547242
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