Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis

Benzodiazepines (BDZs) enhance GABA(A) receptor inhibition by direct actions on central BDZ receptors (CBRs). Although some BDZs also bind mitochondrial receptors [translocator protein (18 kDa) (TSPO)] and promote the synthesis of GABA-enhancing neurosteroids, the role of neurosteroids in the clinic...

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Auteurs principaux: Tokuda, Kazuhiro, O'Dell, Kazuko A., Izumi, Yukitoshi, Zorumski, Charles F.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2010
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073626/
https://ncbi.nlm.nih.gov/pubmed/21159950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4101-10.2010
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