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Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis

Benzodiazepines (BDZs) enhance GABA(A) receptor inhibition by direct actions on central BDZ receptors (CBRs). Although some BDZs also bind mitochondrial receptors [translocator protein (18 kDa) (TSPO)] and promote the synthesis of GABA-enhancing neurosteroids, the role of neurosteroids in the clinic...

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Detalhes bibliográficos
Main Authors: Tokuda, Kazuhiro, O'Dell, Kazuko A., Izumi, Yukitoshi, Zorumski, Charles F.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073626/
https://ncbi.nlm.nih.gov/pubmed/21159950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4101-10.2010
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