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Dihydroisoxazole Analogs for Labeling and Visualization of Catalytically Active Transglutaminase 2
We report the synthesis and preliminary characterization of “clickable” inhibitors of human transglutaminase 2 (TG2). These inhibitors possess the 3-halo-4,5-dihydroisoxazole warhead along with bio-orthogonal groups such as azide or alkyne moieties that enable subsequent covalent modification with f...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3073585/ https://ncbi.nlm.nih.gov/pubmed/21276939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.11.004 |
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