Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation

There is a significant flux of the neurotoxic oxysterol 27-hydroxycholesterol (27OHC) from the circulation across the blood-brain barrier. Because there is a correlation between 27OHC and cholesterol in the circulation and lipoprotein-bound cholesterol does not pass the blood-brain barrier, we have...

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Hlavní autoři: Shafaati, Marjan, Marutle, Amelia, Pettersson, Hanna, Lövgren-Sandblom, Anita, Olin, Maria, Pikuleva, Irina, Winblad, Bengt, Nordberg, Agneta, Björkhem, Ingemar
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2011
Témata:
Patient-Oriented and Epidemiological Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073459/
https://ncbi.nlm.nih.gov/pubmed/21335619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M014548
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