Senescence of activated stellate cells limits liver fibrosis

Cellular senescence acts as a potent mechanism of tumor suppression; however, its functional contribution to non-cancer pathologies has not been examined. Here we show that senescent cells accumulate in murine livers treated to produce fibrosis, a precursor pathology to cirrhosis. The senescent cell...

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Bibliographic Details
Main Authors:	Krizhanovsky, Valery, Yon, Monica, Dickins, Ross A., Hearn, Stephen, Simon, Janelle, Miething, Cornelius, Yee, Herman, Zender, Lars, Lowe, Scott W.
Format:	Artigo
Language:	Inglês
Published:	2008
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3073300/ https://ncbi.nlm.nih.gov/pubmed/18724938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.06.049
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Senescence of activated stellate cells limits liver fibrosis

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