IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner

Hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and cirrhosis determines patient prognosis; however, effective treatment for fibrosis has not been established. Oxidative stress and inflammation activate hepatic stellate cells (HSCs) and promote fibrosis. In contrast, cellular senescence inhi...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Nishizawa, Hitoshi, Iguchi, Genzo, Fukuoka, Hidenori, Takahashi, Michiko, Suda, Kentaro, Bando, Hironori, Matsumoto, Ryusaku, Yoshida, Kenichi, Odake, Yukiko, Ogawa, Wataru, Takahashi, Yutaka
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056388/
https://ncbi.nlm.nih.gov/pubmed/27721459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34605
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items