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The orientation of binding of human immunodeficiency virus reverse transcriptase on nucleic acid hybrids.

The binding of HIV reverse transcriptase (RT) to heteroduplexes was examined using a substrate consisting of a 42 nt chimeric nucleic acid composed. (5'-->3') of 23 nt of RNA and 19 of DNA. This chimera was hybridized to an internal region of a relatively long complementary DNA or RNA. When the chim...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autor principal: DeStefano, J J
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 1995
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307308/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479034/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.19.3901
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