Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome–positive acute lymphoblastic leukemia

The introduction of cultured p185(BCR-ABL)-expressing (p185(+)) Arf (−/−) pre-B cells into healthy syngeneic mice induces aggressive acute lymphoblastic leukemia (ALL) that genetically and phenotypically mimics the human disease. We adapted this high-throughput Philadelphia chromosome–positive (Ph(+...

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Detalhes bibliográficos
Main Authors: Boulos, Nidal, Mulder, Heather L., Calabrese, Christopher R., Morrison, Jeffrey B., Rehg, Jerold E., Relling, Mary V., Sherr, Charles J., Williams, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072880/
https://ncbi.nlm.nih.gov/pubmed/21263154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-301267
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