SLO-1-Channels of Parasitic Nematodes Reconstitute Locomotor Behaviour and Emodepside Sensitivity in Caenorhabditis elegans slo-1 Loss of Function Mutants

The calcium-gated potassium channel SLO-1 in Caenorhabditis elegans was recently identified as key component for action of emodepside, a new anthelmintic drug with broad spectrum activity. In this study we identified orthologues of slo-1 in Ancylostoma caninum, Cooperia oncophora, and Haemonchus con...

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Autors principals: Welz, Claudia, Krüger, Nina, Schniederjans, Monika, Miltsch, Sandra M., Krücken, Jürgen, Guest, Marcus, Holden-Dye, Lindy, Harder, Achim, von Samson-Himmelstjerna, Georg
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072372/
https://ncbi.nlm.nih.gov/pubmed/21490955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001330
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