The Exocyst Protein Sec10 Interacts with Polycystin-2 and Knockdown Causes PKD-Phenotypes

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by formation of renal cysts that destroy the kidney. Mutations in PKD1 and PKD2, encoding polycystins-1 and -2, cause ADPKD. Polycystins are thought to function in primary cilia, but it is not well understood how these and other p...

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Bibliografiske detaljer
Main Authors: Fogelgren, Ben, Lin, Shin-Yi, Zuo, Xiaofeng, Jaffe, Kimberly M., Park, Kwon Moo, Reichert, Ryan J., Bell, P. Darwin, Burdine, Rebecca D., Lipschutz, Joshua H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072367/
https://ncbi.nlm.nih.gov/pubmed/21490950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001361
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