Expression ratio of CCND1 to CDKN2A mRNA predicts RB1 status of cultured cancer cell lines and clinical tumor samples

BACKGROUND: The retinoblastoma product (RB1) is frequently deregulated in various types of tumors by mutation, deletion, or inactivation through association with viral oncoproteins. The functional loss of RB1 is recognized to be one of the hallmarks that differentiate cancer cells from normal cells....

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Bibliographische Detailangaben
Hauptverfasser: Mizuarai, Shinji, Machida, Takumitsu, Kobayashi, Tsutomu, Komatani, Hideya, Itadani, Hiraku, Kotani, Hidehito
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072353/
https://ncbi.nlm.nih.gov/pubmed/21447152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-31
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