Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor

BACKGROUND: Wee1 is a tyrosine kinase regulating S-G2 cell cycle transition through the inactivating phosphorylation of CDC2. The inhibition of Wee1 kinase by a selective small molecule inhibitor significantly enhances the anti-tumor efficacy of DNA damaging agents, specifically in p53 negative tumo...

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Main Authors: Mizuarai, Shinji, Yamanaka, Kazunori, Itadani, Hiraku, Arai, Tsuyoshi, Nishibata, Toshihide, Hirai, Hiroshi, Kotani, Hidehito
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2009
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700070/
https://ncbi.nlm.nih.gov/pubmed/19500427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-34
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