Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is one of the most devastating neurodegenerative diseases. Neurotrophic factors have been widely tested to counteract neurodegenerative conditions, despite their unspecific neuronal access. The non-toxic C-terminal fragment of the tetanus toxin (TTC) h...

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Autores principales: Calvo, Ana C, Moreno-Igoa, María, Mancuso, Renzo, Manzano, Raquel, Oliván, Sara, Muñoz, María J, Penas, Clara, Zaragoza, Pilar, Navarro, Xavier, Osta, Rosario
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072305/
https://ncbi.nlm.nih.gov/pubmed/21418619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-6-10
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