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Loss of TRPC1-mediated Ca(2+) influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells
MC degranulation requires the influx of calcium from the extracellular environment. Orai1/STIM1 is essential to MC SOCE, as shown in rat peritoneal MCs, the rat MC lines (RBL-2H3), or in Orai1 null embryo liver-derived, cultured MCs. However, minimal information exists about the role of other calciu...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Society for Leukocyte Biology
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3072234/ https://ncbi.nlm.nih.gov/pubmed/20571036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0510253 |
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