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Functional complementation between FADD and RIP1 in embryos and lymphocytes
FADD is a common adaptor shared by several death-receptors (DRs) for signaling apoptosis through recruitment and activation of caspase 81-3. DRs are essential for immune homeostasis, but dispensable during embryogenesis. Surprisingly, FADD(−/−) mice die in utero4-5 and conditional deletion of FADD l...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3072026/ https://ncbi.nlm.nih.gov/pubmed/21368761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09878 |
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