Mutation of the Oct-1 POU-specific recognition helix leads to altered DNA binding and influences enhancement of adenovirus DNA replication.

To assess which residues of Oct-1 POU-specific (POUs) are important for DNA recognition and stimulation of adenovirus DNA replication we have mutated 10 residues of the POUs helix-turn-helix motif implicated in DNA contact. Seven of these turned out to have reduced DNA binding affinity. Of these, th...

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Εκδόθηκε σε:	Nucleic Acids Res
Κύριοι συγγραφείς:	van Leeuwen, H C, Strating, M J, Cox, M, Kaptein, R, van der Vliet, P C
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Oxford University Press 1995
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307177/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7667096/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.16.3189
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