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Destabilization of an alpha-helix-bundle protein by helix dipoles.

The finite difference Poisson-Boltzmann method is used to calculate the electrostatic work of assembling the four alpha-helices of Themiste dyscritum hemerythrin to form the protein's observed antiparallel helical bundle. The calculations account for the interaction of each helix dipole with th...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Gilson, M K, Honig, B
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 1989
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286730/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2922396/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.5.1524
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