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Mutation of the Oct-1 POU-specific recognition helix leads to altered DNA binding and influences enhancement of adenovirus DNA replication.

To assess which residues of Oct-1 POU-specific (POUs) are important for DNA recognition and stimulation of adenovirus DNA replication we have mutated 10 residues of the POUs helix-turn-helix motif implicated in DNA contact. Seven of these turned out to have reduced DNA binding affinity. Of these, th...

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Main Authors: van Leeuwen, H C, Strating, M J, Cox, M, Kaptein, R, van der Vliet, P C
格式: Artigo
語言:Inglês
出版: 1995
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC307177/
https://ncbi.nlm.nih.gov/pubmed/7667096
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